What is the MTHFR gene and methylation?

And what does it have to do with mental health, hormones, cardiovascular disease, detox and energy?

It may sound strange but basically stands for Methylenetetrahydrofolate Reductase. The MTHFR gene is needed for the production of MTHFR. A very important enzyme needed for: 

  • The conversion of folate to its usable form to enter cellular pathways
  • Methylation: an important detoxification process in the body and the MTHFR gene influences the enzyme that increases this detox
  • Converting homocysteine to methionine. This is important for protein production
  • Keeping homocysteine low and is important as a preventative measure against cardiovascular disease
  • Production of glutathione, a very important antioxidant for liver function and energy production
  • The production of SAMe- important for mental well being and sleep

So if you have an MTHFR gene mutation, your body’s ability to apply these fundamental processes may be reduced because your ability to produce the enzyme important for these functions is reduced.

“Individuals with low activity of the MTHFR enzyme may present with elevated homocysteine levels, which have been associated with inflammation and heart disease, birth defects, difficult pregnancies, and potentially an impaired ability to detoxify.” Dr Wentz

Clinically, we often see the MTHFR gene mutated in those suffering with:

The MTHFR gene can be affected by many polymorphisms. However, it is the C677T and A1298C that are the most clinically relevant. They are classed as either homozygous (two copies of the gene are affected) or heterozygous (one copy of the gene is affected). Disease risk and symptom manifestation is generally higher in those with a homozygous mutation.
The test is easy and inexpensive. Testing is offered on the Sunshine Coast and Australia Wide. For our international clients, we are able to assist in organising this in your country.

Are you wanting to know if you are affected?
We also offer further methylation genetic testing. We can then offer nutritional recommendations based on your genetic methylation profile.

Book online or click the phone number to speak with our Naturopath support team (07) 5458 4800 .

Sunshine Coast - Brisbane - Gold Coast